Selected article for: "cell cycle and emodin cell cycle arrest"
Author: Dong, Xiaoxv; Ni, Boran; Fu, Jing; Yin, Xingbin; You, Longtai; Leng, Xin; Liang, Xiao; Ni, Jian
Title: Emodin induces apoptosis in human hepatocellular carcinoma HepaRG cells via the mitochondrial caspase-dependent pathway
  • Document date: 2018_8_2
    • ID: 02r8i5n1_30
    Snippet: To the best of our knowledge, this is the first report of emodin-induced apoptosis in HepaRG cells. Based on our data, we summarize the signaling pathways of emodin-induced apoptosis in HepaRG cells (Fig. 8) . In summary, the present study demonstrated that emodin inhibited the proliferation of HepaRG cells and induced cell cycle arrest and apoptosis through the ROS-mediated mitochondrial pathway. Conversely, pre-treatment with NAC partly inhibit.....
    Document: To the best of our knowledge, this is the first report of emodin-induced apoptosis in HepaRG cells. Based on our data, we summarize the signaling pathways of emodin-induced apoptosis in HepaRG cells (Fig. 8) . In summary, the present study demonstrated that emodin inhibited the proliferation of HepaRG cells and induced cell cycle arrest and apoptosis through the ROS-mediated mitochondrial pathway. Conversely, pre-treatment with NAC partly inhibited the emodin-induced apoptosis via the downregulation of ROS-mediated signal cascades.

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