Selected article for: "cell cycle and emodin cell cycle arrest"
Author: Dong, Xiaoxv; Ni, Boran; Fu, Jing; Yin, Xingbin; You, Longtai; Leng, Xin; Liang, Xiao; Ni, Jian
Title: Emodin induces apoptosis in human hepatocellular carcinoma HepaRG cells via the mitochondrial caspase-dependent pathway
  • Document date: 2018_8_2
    • ID: 02r8i5n1_30
    Snippet: To the best of our knowledge, this is the first report of emodin-induced apoptosis in HepaRG cells. Based on our data, we summarize the signaling pathways of emodin-induced apoptosis in HepaRG cells (Fig. 8) . In summary, the present study demonstrated that emodin inhibited the proliferation of HepaRG cells and induced cell cycle arrest and apoptosis through the ROS-mediated mitochondrial pathway. Conversely, pre-treatment with NAC partly inhibit.....
    Document: To the best of our knowledge, this is the first report of emodin-induced apoptosis in HepaRG cells. Based on our data, we summarize the signaling pathways of emodin-induced apoptosis in HepaRG cells (Fig. 8) . In summary, the present study demonstrated that emodin inhibited the proliferation of HepaRG cells and induced cell cycle arrest and apoptosis through the ROS-mediated mitochondrial pathway. Conversely, pre-treatment with NAC partly inhibited the emodin-induced apoptosis via the downregulation of ROS-mediated signal cascades.

    Search related documents:
    Co phrase search for related documents
    • cell cycle and mitochondrial pathway: 1, 2, 3, 4, 5, 6, 7, 8
    • cell cycle and NAC treatment: 1, 2
    • cell cycle and pre NAC treatment: 1
    • cell cycle and present study: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
    • cell cycle and signal cascade: 1
    • cell cycle and signal pathway: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11
    • cell cycle arrest and HepaRG cell: 1
    • cell cycle arrest and mitochondrial pathway: 1, 2, 3, 4, 5
    • cell cycle arrest and NAC treatment: 1
    • cell cycle arrest and pre NAC treatment: 1
    • cell cycle arrest and present study: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10
    • cell cycle arrest and signal pathway: 1, 2, 3
    • emodin induce and mitochondrial pathway: 1, 2
    • emodin induce apoptosis and mitochondrial pathway: 1, 2
    • HepaRG cell and mitochondrial pathway: 1
    • HepaRG cell and present study: 1, 2, 3
    • mitochondrial pathway and pre NAC treatment: 1
    • mitochondrial pathway and present study: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16
    • mitochondrial pathway and signal pathway: 1, 2, 3, 4, 5