Title: Endoplasmic reticulum localization of Sec12p is achieved by two mechanisms: Rer1p-dependent retrieval that requires the transmembrane domain and Rer1p-independent retention that involves the cytoplasmic domain Document date: 1996_7_2
ID: 45x96b5d_38
Snippet: We also observed immunofiuorescence of DSD in Arerl cells. As shown in Fig. 7 , D-F, the ER staining was still obvious in most cells, although the vacuolar staining was also seen (compare with DDD, Fig. 7 , A-C). This indicates that the TMD of Secl2p has an ability of ER localization even in the absence of Rerlp, supporting the aforementioned possibility that it is involved in both Rerlp-dependent and independent mechanisms......
Document: We also observed immunofiuorescence of DSD in Arerl cells. As shown in Fig. 7 , D-F, the ER staining was still obvious in most cells, although the vacuolar staining was also seen (compare with DDD, Fig. 7 , A-C). This indicates that the TMD of Secl2p has an ability of ER localization even in the absence of Rerlp, supporting the aforementioned possibility that it is involved in both Rerlp-dependent and independent mechanisms.
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