Author: Wang, Ziqiang; Zhao, Yiwan; Zhang, Yaou
Title: Viral lncRNA: A regulatory molecule for controlling virus life cycle Document date: 2017_3_23
ID: 213ddk0s_2
Snippet: During viral infection, viruses generate lncRNAs to facilitate virus-induced cytopathicity and pathogenicity [2] . Additionally, host lncRNA expression is profoundly influenced by viral infections. For example, 4729 lncRNAs are upregulated and 6588 are downregulated during human foamy virus (HFV) infection of H293 cells [3] . Additionally, researchers discovered 504 differentially regulated lncRNAs in a whole transcriptome analysis of SARS-CoVinf.....
Document: During viral infection, viruses generate lncRNAs to facilitate virus-induced cytopathicity and pathogenicity [2] . Additionally, host lncRNA expression is profoundly influenced by viral infections. For example, 4729 lncRNAs are upregulated and 6588 are downregulated during human foamy virus (HFV) infection of H293 cells [3] . Additionally, researchers discovered 504 differentially regulated lncRNAs in a whole transcriptome analysis of SARS-CoVinfected mouse lung tissue [4] , and more than 4800 lncRNAs were differentially expressed in rhabdomyosarcoma cells infected with enterovirus 71 [5] . These findings suggest that widespread differential expression of lncRNAs occurs in response to viral infection and the potential roles of these dysregulated lncRNAs in the viral life cycle.
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