Author: Munday, Diane C.; Emmott, Edward; Surtees, Rebecca; Lardeau, Charles-Hugues; Wu, Weining; Duprex, W. Paul; Dove, Brian K.; Barr, John N.; Hiscox, Julian A.
Title: Quantitative Proteomic Analysis of A549 Cells Infected with Human Respiratory Syncytial Virus Document date: 2010_7_20
ID: 2zhaknbi_1
Snippet: Human respiratory syncytial virus (HRSV) 1 is an enveloped RNA virus and a member of the Paramyxoviridae family, which includes common respiratory viruses such as those causing mumps and measles. HRSV is a leading cause of serious lower respiratory tract infections in infants and young children (1) and causes repeated infections throughout life. The severity of illness varies from bronchiolitis and pneumonia to common coldlike symptoms. Particula.....
Document: Human respiratory syncytial virus (HRSV) 1 is an enveloped RNA virus and a member of the Paramyxoviridae family, which includes common respiratory viruses such as those causing mumps and measles. HRSV is a leading cause of serious lower respiratory tract infections in infants and young children (1) and causes repeated infections throughout life. The severity of illness varies from bronchiolitis and pneumonia to common coldlike symptoms. Particular individuals at higher risk of disease include preterm infants, the immunocompromised, and elderly patients. One of the pathologies of the disease is an innate inflammatory response to infection in the lung, which could explain possible links between HRSV and asthma (2, 3) . The pathogenesis of HRSV is not well understood, and to date, the development of a vaccine has been unsuccessful (4) . Understanding the interaction for HRSV in particular, and for other viruses in general, with the host cell proteome, will aid in the design of effective antivirals and the development of possible vaccine strategies (5) .
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