Author: Munday, Diane C.; Emmott, Edward; Surtees, Rebecca; Lardeau, Charles-Hugues; Wu, Weining; Duprex, W. Paul; Dove, Brian K.; Barr, John N.; Hiscox, Julian A.
Title: Quantitative Proteomic Analysis of A549 Cells Infected with Human Respiratory Syncytial Virus Document date: 2010_7_20
ID: 2zhaknbi_68
Snippet: Conclusions-Although RNA synthesis and virus assembly occur in the cytoplasm, HRSV is known to induce nuclear responses in the cell as replication alters host gene expression. The relative changes in the abundance of cellular proteins in HRSV-infected cells observed in this study confirmed aspects of what is already known about changes in the host cell proteome, validating our novel approach and extending this information as well discovering nove.....
Document: Conclusions-Although RNA synthesis and virus assembly occur in the cytoplasm, HRSV is known to induce nuclear responses in the cell as replication alters host gene expression. The relative changes in the abundance of cellular proteins in HRSV-infected cells observed in this study confirmed aspects of what is already known about changes in the host cell proteome, validating our novel approach and extending this information as well discovering novel interactions with defined cellular pathways. The application of LC-MS/MS coupled to SILAC has not been used previously to study negative sense RNA viruses and their interactions with the host cell, and this study is the first that gives a global overview of the host cell response to HRSV infection. This opens up new potential targets for therapeutic intervention and a deeper understanding of viral pathogenesis.
Search related documents:
Co phrase search for related documents- cell nuclear response and host cell: 1, 2, 3
- cell nuclear response and host cell response: 1, 2, 3
- cell nuclear response and nuclear response: 1, 2, 3, 4, 5, 6, 7
- cellular pathway and define cellular pathway: 1
- cellular pathway and gene expression: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19
- cellular pathway and host cell: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19
- cellular pathway and host cell interaction: 1, 2
- cellular pathway and host cell response: 1
- cellular pathway and novel approach: 1
- cellular pathway and nuclear response: 1
- cellular pathway and potential target: 1, 2, 3, 4, 5
- cellular pathway and RNA virus: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11
- cellular pathway and therapeutic intervention: 1, 2
- cellular pathway and viral pathogenesis: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13
- cellular pathway and virus synthesis: 1, 2
- cellular protein and deep understanding: 1
- cellular protein and gene expression: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73
- cellular protein and global overview: 1
- cellular protein and host cell: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73
Co phrase search for related documents, hyperlinks ordered by date