Author: Hölzer, Martin; Schoen, Andreas; Wulle, Julia; Müller, Marcel A.; Drosten, Christian; Marz, Manja; Weber, Friedemann
Title: Virus- and Interferon Alpha-Induced Transcriptomes of Cells from the Microbat Myotis daubentonii Document date: 2019_8_10
ID: 0co6m9af_2
Snippet: Type I IFNs are a group of cytokines that encompass several subtypes, such as IFN-b, IFN-a 1 to 13, and some others (Garcin et al., 2013) . Type III IFNs (IFN-l 1, 2, 3) are similar, but unlike the systemic type I IFNs they act locally on epithelial cells (Hamming et al., 2010) . IFN induction occurs by cellular sensing of viral RNA structures, resulting in the activation of IFN transcription factors, such as IRF3. The oncesecreted IFNs bind to t.....
Document: Type I IFNs are a group of cytokines that encompass several subtypes, such as IFN-b, IFN-a 1 to 13, and some others (Garcin et al., 2013) . Type III IFNs (IFN-l 1, 2, 3) are similar, but unlike the systemic type I IFNs they act locally on epithelial cells (Hamming et al., 2010) . IFN induction occurs by cellular sensing of viral RNA structures, resulting in the activation of IFN transcription factors, such as IRF3. The oncesecreted IFNs bind to their receptor, activate the transcription factors STAT1/2 via the JAK kinases, and drive the expression of multiple IFN-stimulated genes (ISGs) with antiviral and immunomodulatory activity (Schoggins, 2014) .
Search related documents:
Co phrase search for related documents- epithelial cell and IFN stimulate: 1
- epithelial cell and IFN transcription factor: 1, 2, 3, 4
- epithelial cell and JAK kinase: 1, 2
- epithelial cell and receptor bind: 1, 2
- epithelial cell and RNA structure: 1
- epithelial cell and systemic type: 1
- epithelial cell and transcription factor: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29
- epithelial cell and type iii ifn: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15
- IFN induction and JAK kinase: 1, 2, 3
- IFN induction and receptor bind: 1
- IFN induction and RNA structure: 1, 2, 3
- IFN induction and systemic type: 1, 2, 3, 4, 5
- IFN induction and transcription factor: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36
- IFN induction and transcription factor activate: 1
- IFN induction and type iii ifn: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48
- IFN stimulate and systemic type: 1, 2
- IFN stimulate and transcription factor: 1, 2, 3
- IFN stimulate and type iii ifn: 1, 2, 3
- ifn systemic type and locally act: 1
Co phrase search for related documents, hyperlinks ordered by date