Selected article for: "antiviral activity and ifn antiviral activity"
Author: Hölzer, Martin; Schoen, Andreas; Wulle, Julia; Müller, Marcel A.; Drosten, Christian; Marz, Manja; Weber, Friedemann
Title: Virus- and Interferon Alpha-Induced Transcriptomes of Cells from the Microbat Myotis daubentonii
  • Document date: 2019_8_10
    • ID: 0co6m9af_2
    Snippet: Type I IFNs are a group of cytokines that encompass several subtypes, such as IFN-b, IFN-a 1 to 13, and some others (Garcin et al., 2013) . Type III IFNs (IFN-l 1, 2, 3) are similar, but unlike the systemic type I IFNs they act locally on epithelial cells (Hamming et al., 2010) . IFN induction occurs by cellular sensing of viral RNA structures, resulting in the activation of IFN transcription factors, such as IRF3. The oncesecreted IFNs bind to t.....
    Document: Type I IFNs are a group of cytokines that encompass several subtypes, such as IFN-b, IFN-a 1 to 13, and some others (Garcin et al., 2013) . Type III IFNs (IFN-l 1, 2, 3) are similar, but unlike the systemic type I IFNs they act locally on epithelial cells (Hamming et al., 2010) . IFN induction occurs by cellular sensing of viral RNA structures, resulting in the activation of IFN transcription factors, such as IRF3. The oncesecreted IFNs bind to their receptor, activate the transcription factors STAT1/2 via the JAK kinases, and drive the expression of multiple IFN-stimulated genes (ISGs) with antiviral and immunomodulatory activity (Schoggins, 2014) .

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