Author: Hölzer, Martin; Schoen, Andreas; Wulle, Julia; Müller, Marcel A.; Drosten, Christian; Marz, Manja; Weber, Friedemann
Title: Virus- and Interferon Alpha-Induced Transcriptomes of Cells from the Microbat Myotis daubentonii Document date: 2019_8_10
ID: 0co6m9af_30
Snippet: As mentioned, previous transcriptional profiling studies of bats overwhelmingly used weak IFN inducer viruses or IFN and megabat cells, and only one study so far (again in megabats [Glennon et al., 2015] ) used a truly IFN-inducing virus. Moreover, a global, side-by-side comparison between virus-and IFN-stimulated transcriptomes seems not to exist for any species, not even for humans. In addition to the points raised earlier on IFN subtypes and I.....
Document: As mentioned, previous transcriptional profiling studies of bats overwhelmingly used weak IFN inducer viruses or IFN and megabat cells, and only one study so far (again in megabats [Glennon et al., 2015] ) used a truly IFN-inducing virus. Moreover, a global, side-by-side comparison between virus-and IFN-stimulated transcriptomes seems not to exist for any species, not even for humans. In addition to the points raised earlier on IFN subtypes and ISGs, we compared some of our findings with the distinctive results from previous bat studies.
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