Author: Mok, Hoyin; Cheng, Xing; Xu, Qi; Zengel, James R; Parhy, Bandita; Zhao, Jackie; Wang, C. Kathy; Jin, Hong
Title: Evaluation of Measles Vaccine Virus as a Vector to Deliver Respiratory Syncytial Virus Fusion Protein or Epstein-Barr Virus Glycoprotein gp350 Document date: 2012_2_16
ID: 3qdjmb2j_42
Snippet: Based on our study, MV vector is probably not suitable for delivery of the EBV gp350 antigen. Immunogenicity of adjuvanted gp350 protein vaccine has been demonstrated in young adults [29] , adjvanted gp350 might be the right approach for EBV vaccine development. The amount of gp350 delivered by MV is likely not sufficient to induce gp350 specific immune response. The F protein of RSV delivered by MV is more immunogenic than EBV gp350, however, ad.....
Document: Based on our study, MV vector is probably not suitable for delivery of the EBV gp350 antigen. Immunogenicity of adjuvanted gp350 protein vaccine has been demonstrated in young adults [29] , adjvanted gp350 might be the right approach for EBV vaccine development. The amount of gp350 delivered by MV is likely not sufficient to induce gp350 specific immune response. The F protein of RSV delivered by MV is more immunogenic than EBV gp350, however, additional evaluation of immunogenicity of MV-RSV F must be conduced before proceeding to testing this vaccine in humans.
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