Selected article for: "acid amino mutation and amino mutation"
Author: Tuplin, A.; Evans, D. J.; Buckley, A.; Jones, I. M.; Gould, E. A.; Gritsun, T. S.
Title: Replication enhancer elements within the open reading frame of tick-borne encephalitis virus and their evolution within the Flavivirus genus
  • Document date: 2011_5_27
    • ID: 0aiaklrn_50
    Snippet: Mutation C15, which shortened the apical loop (Figure 4) , did not affect virus growth but changed the plaque morphology and delayed the development of cpe (Table 1 and Figure 5 ). The C15 mutation altered the amino acid M 33 !L, which imitates the KFDV/AHFV group (Figure 3) , potentially contributing to the observed biological effect. Mutation C21 that reduced the apical loop size (Figure 4 ) interfering with exposure of the hexanucleotide, also.....
    Document: Mutation C15, which shortened the apical loop (Figure 4) , did not affect virus growth but changed the plaque morphology and delayed the development of cpe (Table 1 and Figure 5 ). The C15 mutation altered the amino acid M 33 !L, which imitates the KFDV/AHFV group (Figure 3) , potentially contributing to the observed biological effect. Mutation C21 that reduced the apical loop size (Figure 4 ) interfering with exposure of the hexanucleotide, also had a moderate affect on virus growth although the accompanying effect of amino acid substitution Q 32 !H (Figure 3 ) cannot be excluded (Table 1 and Figure 5 ).

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