Selected article for: "gene sequence and high conservation"
Author: MYRRHA, Luciana Wanderley; SILVA, Fernanda Miquelitto Figueira; VIDIGAL, Pedro Marcus Pereira; RESENDE, Maurício; BRESSAN, Gustavo Costa; FIETTO, Juliana Lopes Rangel; SANTOS, Marcus Rebouças; SILVA, Laura Morais Nascimento; ASSAO, Viviane Sisdelli; SILVA-JÚNIOR, Abelardo; de ALMEIDA, Márcia Rogéria
Title: Feline coronavirus isolates from a part of Brazil: insights into molecular epidemiology and phylogeny inferred from the 7b gene
  • Document date: 2019_8_23
    • ID: 1s25r3o0_22
    Snippet: With higher conservation of 7b gene sequence, the Brazilian isolates presented only seven polymorphic sites. Most of these polymorphisms were predicted to be neutral sites in the estimation of selection pressure, seeming to be random and not correlated with the virulence of strains. This high conservation of the 7b gene among Brazilian FCoV isolates shows that the internal mutation theory [1, 23, 31] possibly could not be considered for this gene.....
    Document: With higher conservation of 7b gene sequence, the Brazilian isolates presented only seven polymorphic sites. Most of these polymorphisms were predicted to be neutral sites in the estimation of selection pressure, seeming to be random and not correlated with the virulence of strains. This high conservation of the 7b gene among Brazilian FCoV isolates shows that the internal mutation theory [1, 23, 31] possibly could not be considered for this gene. According to this theory, virulent strains (FIPV) evolve from avirulent strains (FECV) by mutation during infection in cats.

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