Author: Poltronieri, Palmiro; Sun, Binlian; Mallardo, Massimo
Title: RNA Viruses: RNA Roles in Pathogenesis, Coreplication and Viral Load Document date: 2015_10_23
ID: 259cspey_62
Snippet: The HIV-1 transcriptional activator Tat has evolved mechanisms to resolve the transcription block. Tat is associated with histone acetyl transferase (HAT) proteins whose activities remodel nucleosomes to allow transcriptional access. Tat has been shown to bind several different HATs: CBP/p300, p/CAF, GCN5, Tip60, and TAFII250. Through binding to the HAT proteins, Tat relieves chromatin repression at the HIV-1 LTR. Recently, Tat has also been foun.....
Document: The HIV-1 transcriptional activator Tat has evolved mechanisms to resolve the transcription block. Tat is associated with histone acetyl transferase (HAT) proteins whose activities remodel nucleosomes to allow transcriptional access. Tat has been shown to bind several different HATs: CBP/p300, p/CAF, GCN5, Tip60, and TAFII250. Through binding to the HAT proteins, Tat relieves chromatin repression at the HIV-1 LTR. Recently, Tat has also been found to bind a histone chaperone protein, hNAP-1, which acts with ATP-dependent chromatin remodeling complexes to facilitate transcription.
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