Selected article for: "gene expression and global comparison"
Author: Sousa, Carole; Golebiewska, Anna; Poovathingal, Suresh K; Kaoma, Tony; Pires-Afonso, Yolanda; Martina, Silvia; Coowar, Djalil; Azuaje, Francisco; Skupin, Alexander; Balling, Rudi; Biber, Knut; Niclou, Simone P; Michelucci, Alessandro
Title: Single-cell transcriptomics reveals distinct inflammation-induced microglia signatures
  • Document date: 2018_9_11
    • ID: 0662rivp_12
    Snippet: They identify two populations of microglia after LPS-induced systemic inflammation based on gene expression (termed 'Main LPS' and 'Subset LPS'). The authors however provide only a global comparison between the two populations. Therefore, a more specific description of the top genes that distinguish the two populations would be useful. Moreover, the authors could use other methods to confirm this heterogeneity, such as FACS based on differentiall.....
    Document: They identify two populations of microglia after LPS-induced systemic inflammation based on gene expression (termed 'Main LPS' and 'Subset LPS'). The authors however provide only a global comparison between the two populations. Therefore, a more specific description of the top genes that distinguish the two populations would be useful. Moreover, the authors could use other methods to confirm this heterogeneity, such as FACS based on differentially expressed surface markers, and immunohistochemistry to define the location of the 'subset' population. What is the difference of this 'subset' population in terms of function, proliferation and cytokine expression in comparison to the 'main' LPS population and naïve microglia? Can this population be analyzed longitudinally? When does it appear? How long does it persist?

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