Author: Sousa, Carole; Golebiewska, Anna; Poovathingal, Suresh K; Kaoma, Tony; Pires-Afonso, Yolanda; Martina, Silvia; Coowar, Djalil; Azuaje, Francisco; Skupin, Alexander; Balling, Rudi; Biber, Knut; Niclou, Simone P; Michelucci, Alessandro
Title: Single-cell transcriptomics reveals distinct inflammation-induced microglia signatures Document date: 2018_9_11
ID: 0662rivp_12
Snippet: They identify two populations of microglia after LPS-induced systemic inflammation based on gene expression (termed 'Main LPS' and 'Subset LPS'). The authors however provide only a global comparison between the two populations. Therefore, a more specific description of the top genes that distinguish the two populations would be useful. Moreover, the authors could use other methods to confirm this heterogeneity, such as FACS based on differentiall.....
Document: They identify two populations of microglia after LPS-induced systemic inflammation based on gene expression (termed 'Main LPS' and 'Subset LPS'). The authors however provide only a global comparison between the two populations. Therefore, a more specific description of the top genes that distinguish the two populations would be useful. Moreover, the authors could use other methods to confirm this heterogeneity, such as FACS based on differentially expressed surface markers, and immunohistochemistry to define the location of the 'subset' population. What is the difference of this 'subset' population in terms of function, proliferation and cytokine expression in comparison to the 'main' LPS population and naïve microglia? Can this population be analyzed longitudinally? When does it appear? How long does it persist?
Search related documents:
Co phrase search for related documents- cytokine expression and gene expression: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73, 74, 75
- cytokine expression and LPS induce: 1, 2, 3
- cytokine expression and surface marker: 1, 2
- cytokine expression and systemic inflammation: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18
- cytokine expression proliferation and gene expression: 1, 2
Co phrase search for related documents, hyperlinks ordered by date