Generation and protective efficacy of a cold-adapted attenuated genotype 2b porcine epidemic diarrhea virus

Won, Hokeun; Lee, Dong-Uk; Jang, Guehwan; Noh, Yun-Hee; Lee, Seung-Chul; Choi, Hwan-Won; Yoon, In-Joong; Yoo, Han Sang; Lee, Changhee

The challenges of substantial monetary damage caused by PEDV highlight the exigent necessity for the establishment of optimal immunization strategies. In most cases of porcine enteric viruses that produce clinical disease in newborn piglets before the development of active immunity, the neonates are protected by passive lactogenic immunity derived from the dams [14] [15] [16] . Prophylactic maternal immunization regimens with oral live viruses, including intentional infection and vaccination of sows during gestation, remain the most effective way to stimulate intestinal mucosal immunity that is subsequently transferred to piglets via mammary secretions [15, 17] . Although intentional infection or feedback through controlled oral exposure is extensively used to induce herd immunity, there are several potential risks associated with this practices such as the wide dissemination of other microbial pathogens and the uncertainty of immune induction [1, 2, 15] . Therefore, numerous research groups are attempting to develop safer and more effective live attenuated PEDV vaccines to induce passive lactogenic immunity as an alternative to intentional infection.