Selected article for: "error rate and proofreading hypothesis"
Author: Deng, Zengqin; Lehmann, Kathleen C.; Li, Xiaorong; Feng, Chong; Wang, Guoqiang; Zhang, Qi; Qi, Xiaoxuan; Yu, Lin; Zhang, Xingliang; Feng, Wenhai; Wu, Wei; Gong, Peng; Tao, Ye; Posthuma, Clara C.; Snijder, Eric J.; Gorbalenya, Alexander E.; Chen, Zhongzhou
Title: Structural basis for the regulatory function of a complex zinc-binding domain in a replicative arterivirus helicase resembling a nonsense-mediated mRNA decay helicase
  • Document date: 2013_12_24
    • ID: 471zei5o_35
    Snippet: Among +RNA viruses, whose RdRps generally have a high error rate, nidoviruses stand out for their large to very large genome size (13-32 kb) . Consequently, the replication fidelity of nidoviruses, in particular coronaviruses, has been the subject of intense study. Most recently, the identification of a unique 3 0 -to-5 0 exoribonuclease (ExoN) activity has provided the basis for the hypothesis that a primitive proofreading mechanism operates to .....
    Document: Among +RNA viruses, whose RdRps generally have a high error rate, nidoviruses stand out for their large to very large genome size (13-32 kb) . Consequently, the replication fidelity of nidoviruses, in particular coronaviruses, has been the subject of intense study. Most recently, the identification of a unique 3 0 -to-5 0 exoribonuclease (ExoN) activity has provided the basis for the hypothesis that a primitive proofreading mechanism operates to promote the fidelity of RNA-dependent RNA synthesis in nidoviruses with >20 kb genomes (21) (22) (23) (24) (25) (26) (27) .

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