Selected article for: "available information and protein function"

Author: Blazejewski, Tomasz; Nursimulu, Nirvana; Pszenny, Viviana; Dangoudoubiyam, Sriveny; Namasivayam, Sivaranjani; Chiasson, Melissa A.; Chessman, Kyle; Tonkin, Michelle; Swapna, Lakshmipuram S.; Hung, Stacy S.; Bridgers, Joshua; Ricklefs, Stacy M.; Boulanger, Martin J.; Dubey, Jitender P.; Porcella, Stephen F.; Kissinger, Jessica C.; Howe, Daniel K.; Grigg, Michael E.; Parkinson, John
Title: Systems-Based Analysis of the Sarcocystis neurona Genome Identifies Pathways That Contribute to a Heteroxenous Life Cycle
  • Document date: 2015_2_10
  • ID: 64mb9smi_17
    Snippet: Overall, S. neurona contains a smaller complement of ROPKs (n Ï­ 15) than E. tenella (n Ï­ 27) and a considerably smaller set than T. gondii (n Ï­ 55) and N. caninum (n Ï­ 44), both of which feature distinct lineage-specific expansions. However, despite its lower number of ROPKs, S. neurona was found to have more ROPKs in common with T. gondii and N. caninum than with E. tenella; only two of the ROPKs in the three tissue cyst-forming coccidia are.....
    Document: Overall, S. neurona contains a smaller complement of ROPKs (n Ï­ 15) than E. tenella (n Ï­ 27) and a considerably smaller set than T. gondii (n Ï­ 55) and N. caninum (n Ï­ 44), both of which feature distinct lineage-specific expansions. However, despite its lower number of ROPKs, S. neurona was found to have more ROPKs in common with T. gondii and N. caninum than with E. tenella; only two of the ROPKs in the three tissue cyst-forming coccidia are conserved with E. tenella (ROP21/27 and ROP35), Importantly, we did not find S. neurona homologs corresponding to T. gondii ROPK proteins implicated in murine virulence (ROP5 and ROP18), modulation of STAT3 and STAT6 signaling (ROP16), or mitogen-activated protein (MAP) kinase signaling (ROP38), which suggests that S. neurona's success and pathogenesis are not dependent on the inactivation of these host-specific pathways and may explain, in part, why this parasite is not infectious in rodents. No information is available regarding the functional role of S. neurona ROPKs. However, six are likely to be active kinases since they retain key "catalytic triad" residues critical for protein kinase function (SnROP21/27, SnROP30, SnROP33, SnROP34, SnROP35). Further, five are likely to be pseudokinases (SnROP20, SnROP22, SnROP26, SnROP36, SnROP37) that have been shown to act as cofactors of the active kinases (e.g., SnROP5 to SnROP18).

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