Selected article for: "cytokine production and sickness behavior"

Author: William Binning; Aja E. Hogan-Cann; Diana Yae Sakae; Matthew Maksoud; Valeriy Ostapchenko; Mohammed Al-Onaizi; Sara Matovic; Wei-Yang Lu; Marco A. M. Prado; Wataru Inoue; Vania F. Prado
Title: Chronic hM3Dq signaling in microglia ameliorates neuroinflammation in male mice
  • Document date: 2020_1_28
  • ID: ely200x3_110
    Snippet: Recurrent hM3Dq activation also diminished LPS-induced cytokine production and prevented LPS-induced sickness behavior, raising an intriguing possibility that hM3Dq-signaling alone could lead to microglial immune memory formation. Remarkably, pharmacological studies using muscarinic M3-knockout mice showed that in the periphery, M3-signaling is important for immune author/funder. All rights reserved. No reuse allowed without permission......
    Document: Recurrent hM3Dq activation also diminished LPS-induced cytokine production and prevented LPS-induced sickness behavior, raising an intriguing possibility that hM3Dq-signaling alone could lead to microglial immune memory formation. Remarkably, pharmacological studies using muscarinic M3-knockout mice showed that in the periphery, M3-signaling is important for immune author/funder. All rights reserved. No reuse allowed without permission.

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