Author: Heaton, Steven M.; Borg, Natalie A.; Dixit, Vishva M.
Title: Ubiquitin in the activation and attenuation of innate antiviral immunity Document date: 2016_1_11
ID: 42d77vxf_1
Snippet: The frontline in the cellular response to viral infection is comprised of the specific and general effectors of the innate immune system. Effector molecule production is initiated by immune sentinels known as pattern recognition receptors (PRRs), which screen the intra-and extracellular environment for molecular motifs uniquely associated with pathogens. PRR engagement transduces pro-immune signals into the nucleus via protein signaling cascades .....
Document: The frontline in the cellular response to viral infection is comprised of the specific and general effectors of the innate immune system. Effector molecule production is initiated by immune sentinels known as pattern recognition receptors (PRRs), which screen the intra-and extracellular environment for molecular motifs uniquely associated with pathogens. PRR engagement transduces pro-immune signals into the nucleus via protein signaling cascades that self-limit to mitigate autoimmunity as the infection clears (Crampton et al., 2012) . Protein posttranslational modifications (PTMs) form part of this exquisite system of regulation, with ubiquitin and ubiquitin-like modifications key among them.
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