Author: Heaton, Steven M.; Borg, Natalie A.; Dixit, Vishva M.
Title: Ubiquitin in the activation and attenuation of innate antiviral immunity Document date: 2016_1_11
ID: 42d77vxf_7
Snippet: At rest, the RLR cascade is maintained in an inactive but tensioned state through an intricate negative feedback system involving protein expression levels, conformational changes, compartmentalization, and PTMs. Part of this system operates at the receptor through conformational auto-inhibition of the RIG-I CARDs. The RIG-I C-terminal repressor domain (RD) audits the cytosol for viral RNA, binding of which induces a major structural rearrangemen.....
Document: At rest, the RLR cascade is maintained in an inactive but tensioned state through an intricate negative feedback system involving protein expression levels, conformational changes, compartmentalization, and PTMs. Part of this system operates at the receptor through conformational auto-inhibition of the RIG-I CARDs. The RIG-I C-terminal repressor domain (RD) audits the cytosol for viral RNA, binding of which induces a major structural rearrangement in the RD and CARD (Saito et al., 2007) . Conversely, MDA5 oligomerizes along the length of RNA ligands, forming immunogenic filaments that are potentiated by ATP hydrolysis and interaction with LGP2 (Peisley et al., 2012; Bruns et al., 2014) .
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