Author: Abdul-Rasool, Sahar; Fielding, Burtram C
Title: Understanding Human Coronavirus HCoV-NL63 Document date: 2010_5_25
ID: 3ahp9tli_15
Snippet: Coronavirus genomes contain accessory genes found interspersed among the structural genes, which vary in number and location between the different coronavirus groups (Fig. 1) . Both HCoV-NL63 and HCoV-229E are group I coronaviruses and encode for only one accessory gene product between the S and E genes [34] . Accessory genes are poorly characterized and the functions of the gene products are not well understood. Initial research into the functio.....
Document: Coronavirus genomes contain accessory genes found interspersed among the structural genes, which vary in number and location between the different coronavirus groups (Fig. 1) . Both HCoV-NL63 and HCoV-229E are group I coronaviruses and encode for only one accessory gene product between the S and E genes [34] . Accessory genes are poorly characterized and the functions of the gene products are not well understood. Initial research into the functions of these genes has shown that they are nonessential and dispensable for virus growth in cell culture [5, 6, 35] . More recent studies have shown that the accessory genes are required for in vivo infection and pathogenecity in the natural host [6, 7, [36] [37] [38] .
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