Author: Abdul-Rasool, Sahar; Fielding, Burtram C
Title: Understanding Human Coronavirus HCoV-NL63 Document date: 2010_5_25
ID: 3ahp9tli_2
Snippet: Coronaviruses (CoVs) belong to the family Coronaviridae in the order nidovirales. Members of the Coronavirus family are positive-strand RNA viruses with large genomes ranging in size from 27-33 kb. The coronavirus genome encodes for a 5 replicase polyprotein (ORF1a and ORF1b) that, in turn, encodes for all the enzymes required for viral RNA replication. The genome also encodes for the 3 structural proteins, including spike (S), envelope (E), memb.....
Document: Coronaviruses (CoVs) belong to the family Coronaviridae in the order nidovirales. Members of the Coronavirus family are positive-strand RNA viruses with large genomes ranging in size from 27-33 kb. The coronavirus genome encodes for a 5 replicase polyprotein (ORF1a and ORF1b) that, in turn, encodes for all the enzymes required for viral RNA replication. The genome also encodes for the 3 structural proteins, including spike (S), envelope (E), membrane (M) and nucleocapsid (N), which are common to all coronaviruses. The structural proteins are involved in various viral processes, including virus particle formation [4] . Additional subgroup-specific accessory genes are found interspersed among the structural genes, which vary in number and location. Recent studies have shown that the proteins encoded by these genes could be modulators of pathogenicity in the natural host [5] [6] [7] . § These authors made equal contribution.
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