Author: Bahir, Iris; Fromer, Menachem; Prat, Yosef; Linial, Michal
Title: Viral adaptation to host: a proteome-based analysis of codon usage and amino acid preferences Document date: 2009_10_13
ID: 629kl04a_38
Snippet: Testing codon and amino acids usage (rather than more direct measures of substitution and mutation rate) has the advantage that it provides a view on the variability of the viral proteome relative to its potential hosts (Figures 4-6) . Nonetheless, our observations cannot provide insights into the dynamics or rates of viral evolution. Studies that estimate the diversity among viruses and their hosts often focus on those having high enough mutatio.....
Document: Testing codon and amino acids usage (rather than more direct measures of substitution and mutation rate) has the advantage that it provides a view on the variability of the viral proteome relative to its potential hosts (Figures 4-6) . Nonetheless, our observations cannot provide insights into the dynamics or rates of viral evolution. Studies that estimate the diversity among viruses and their hosts often focus on those having high enough mutation rates or short generation times, resulting in increased genetic diversity (van Hemert et al, 2007) . Our analysis is thus complementary to such studies.
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