Author: Hölzer, Martin; Schoen, Andreas; Wulle, Julia; Müller, Marcel A.; Drosten, Christian; Marz, Manja; Weber, Friedemann
Title: Virus- and Interferon Alpha-Induced Transcriptomes of Cells from the Microbat Myotis daubentonii Document date: 2019_8_10
ID: 0co6m9af_21
Snippet: Literature and database searches were done to find information about these genes that we found to behave like IFNB1. As remarked earlier, the transcriptomes published so far were from either virus-infected or from IFN-treated cells but not from both in parallel. Thus, transcriptomes as well as most studies on individual ISGs could not clearly distinguish between primary (i.e., virus dependent) and secondary (virusinduced IFN) responses to infecti.....
Document: Literature and database searches were done to find information about these genes that we found to behave like IFNB1. As remarked earlier, the transcriptomes published so far were from either virus-infected or from IFN-treated cells but not from both in parallel. Thus, transcriptomes as well as most studies on individual ISGs could not clearly distinguish between primary (i.e., virus dependent) and secondary (virusinduced IFN) responses to infection, thus impeding a clear distinction of gene expressions that are unique for either of these triggers. Moreover, Ruxolitinib was not used before to systematically study IFN-independent cell responses to virus infection. Hence, we had aimed to clearly differentiate true virus-response genes from conventional ISGs indirectly activated by virus-induced IFN. Thus, we propose CCL4 to be an apparently conserved (humans, megabats, microbats) virus response gene.
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