Author: Welch, Matthew D.
Title: Why should cell biologists study microbial pathogens? Document date: 2015_12_1
ID: 04xyhhmf_19
Snippet: In cases in which vaccination is not possible or fails to confer protection, antiviral, antibacterial, and antiparasitic drugs are commonly used to treat infections. These drugs generally target pathogen molecules that are both essential for pathogen growth and are distinct from host molecules, enhancing the selective toxicity of the drug for the infectious agent while minimizing side effects on the host. This raises the following question: Can h.....
Document: In cases in which vaccination is not possible or fails to confer protection, antiviral, antibacterial, and antiparasitic drugs are commonly used to treat infections. These drugs generally target pathogen molecules that are both essential for pathogen growth and are distinct from host molecules, enhancing the selective toxicity of the drug for the infectious agent while minimizing side effects on the host. This raises the following question: Can host cell components that are important for pathogenesis also be effective drug targets for treating infectious diseases? The answer is yes, and it is noteworthy that targeting host molecules appears to be an emerging strategy for the development of drugs to treat infections.
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