Author: Baum, Alina; García-Sastre, Adolfo
Title: Induction of type I interferon by RNA viruses: cellular receptors and their substrates Document date: 2009_11_1
ID: 4c1nuv2p_6
Snippet: Because early interference experiments relied on inactivated virus as the inducer of interferon response, attempts were made to connect the induction by isolated RNA to that of inactivated virus. An initial report showed that RNA is produced from UV treated Newcastle Disease Virus (NDV) virions even though there is a complete loss of infectivity as measured by plaque assay (Huppert et al. 1969) . Thus, it appeared that UV treated virions attempt .....
Document: Because early interference experiments relied on inactivated virus as the inducer of interferon response, attempts were made to connect the induction by isolated RNA to that of inactivated virus. An initial report showed that RNA is produced from UV treated Newcastle Disease Virus (NDV) virions even though there is a complete loss of infectivity as measured by plaque assay (Huppert et al. 1969) . Thus, it appeared that UV treated virions attempt to replicate and produce at least partially synthesized RNA even in the absence of producing functional viral progeny. This incomplete newly synthesized RNA is thought to base pair with the template resulting in the formation of a dsRNA molecule.
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