Clinical characteristics of 34 COVID-19 patients admitted to ICU in Hangzhou, China

Yi Zheng; Lijun Sun; Mi Xu; Jian Pan; Yuntao Zhang; Xueling Fang; Qiang Fang; Hongliu Cai

By 5 March 2020, 35 cases infected with SARS-CoV-2 in ICU at the First Affiliated Hospital, College of Medicine，Zhejiang University, Hangzhou were investigated. Of the 35 cases, an infected pregnant woman admitted to ICU after caesarean section was excluded because she was an exception and didn't measure up to the ICU admissions standard. Finally, 34 cases were included in the study. None was residents of Wuhan City. No patients had direct exposure to Huanan seafood market and only 9 patients had been exposed to individuals with confirmed SARS-Cov-2 infection or clustering onset. 17 cases had history of sojourn in epidemic area or close contacted with people from the epidemic area. 8 had no history of any of the above. The median duration from onset of symptoms to the time of first nucleic acid test positive was 4 (IQR 1-7) days. The median duration from onset of symptoms to ICU admission was 10.0 (7·0-11·3) days, to HFNC was 10 (7-11) days in 27 patients, to IMV was 11(8-12) days in 15 cases, to ECMO was 23(18-29) days in 11 patients. (Fig 1) The median age was 66 years (IQR 58-76 years) and 23 (67.6%) were men. 24 (70.6%) patients had chronic diseases, including hypertension (64.7%), diabetes (23.5%), cardiovascular disease (11.8%), chronic obstructive pulmonary disease (5.9%), chronic liver disease (11.8%), chronic kidney disease (5.9%). The most common symptoms at onset of illness were fever (58.8%), dry cough (20.6%), and expectoration (29.4%; table 1), relative less common initial symptoms were myalgia (14.7%), fatigue (5.9%), diarrhea (5.9%), headache (5.9%). The proportion of different comorbidities and the distribution of first symptoms did not differ obviously. (Table 1) The blood cells counts on admission showed that leukocytosis (white blood cell count more All rights reserved. No reuse allowed without permission. author/funder, who has granted medRxiv a license to display the preprint in perpetuity.