Author: Darwish, Ilyse; Miller, Chris; Kain, Kevin C.; Liles, W. Conrad
Title: Inhaled Nitric Oxide Therapy Fails to Improve Outcome in Experimental Severe Influenza Document date: 2012_1_13
ID: 1rktb6yq_12
Snippet: iNO therapy is currently FDA approved for the treatment of term and near-term neonates with hypoxemic respiratory failure associated with clinical or echocardiographic evidence of pulmonary arterial hypertension (26, 27) . Variable findings have been reported for iNO efficacy when administered at 1 ppm and up to 80 ppm. For its indicated use, iNO has been found to increase vasodilation, improve oxygenation, reduce length of mechanical ventilation.....
Document: iNO therapy is currently FDA approved for the treatment of term and near-term neonates with hypoxemic respiratory failure associated with clinical or echocardiographic evidence of pulmonary arterial hypertension (26, 27) . Variable findings have been reported for iNO efficacy when administered at 1 ppm and up to 80 ppm. For its indicated use, iNO has been found to increase vasodilation, improve oxygenation, reduce length of mechanical ventilation, reduce oxygen requirement, and decrease length of stay in the intensive care unit (27, 30, 31) . However, systematic reviews have failed to demonstrate that iNO therapy reduces overall mortality (32, 33) .
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