Author: Menachery, Vineet D.; Schäfer, Alexandra; Burnum-Johnson, Kristin E.; Mitchell, Hugh D.; Eisfeld, Amie J.; Walters, Kevin B.; Nicora, Carrie D.; Purvine, Samuel O.; Casey, Cameron P.; Monroe, Matthew E.; Weitz, Karl K.; Stratton, Kelly G.; Webb-Robertson, Bobbie-Jo M.; Gralinski, Lisa E.; Metz, Thomas O.; Smith, Richard D.; Waters, Katrina M.; Sims, Amy C.; Kawaoka, Yoshihiro; Baric, Ralph S.
Title: MERS-CoV and H5N1 influenza virus antagonize antigen presentation by altering the epigenetic landscape Document date: 2018_1_30
ID: 096gtdy5_2
Snippet: antigen presentation | epigenetics | coronavirus | influenza | DNA methylation S ince the beginning of the new century, the emergence of novel influenza and coronavirus (CoV) strains has led to significant pandemics and poses a continuing threat to global public health (1) (2) (3) . Understanding how these respiratory pathogens induce disease is key for treatment and prevention strategies (1) . For successful respiratory viruses, multiple element.....
Document: antigen presentation | epigenetics | coronavirus | influenza | DNA methylation S ince the beginning of the new century, the emergence of novel influenza and coronavirus (CoV) strains has led to significant pandemics and poses a continuing threat to global public health (1) (2) (3) . Understanding how these respiratory pathogens induce disease is key for treatment and prevention strategies (1) . For successful respiratory viruses, multiple elements of the host immune response must be overcome, including both innate and adaptive immunity (1, 3) . While these immune mechanisms are relatively conserved, complex interactions govern disease outcome, and successful viruses use a combination of approaches to combat host immunity. Even among related viruses, diverse strategies may produce similar infection results through distinct mechanisms (4) . Therefore, susceptibility to a host pathway may not be uniform across a viral family or apply to all viruses infecting the same tissue. In exploring these responses, cross-comparisons may identify common strategies used by different viruses to antagonize the host immune responses. In our approach, we sought to leverage differences and similarities between respiratory pathogens to identify novel viral antagonism strategies (5) .
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