Author: Lundegaard, Claus; Lund, Ole; Kesmir, Can; Brunak, Søren; Nielsen, Morten
Title: Modeling the adaptive immune system: predictions and simulations Document date: 2007_12_15
ID: 5m269nzi_24
Snippet: B-cell epitope prediction is a highly challenging field due to the fact that the vast majority of antibodies raised against a specific protein interact with discontinuous fragments (van Regenmortel, 1996) . The prediction of continuous, or linear, epitopes, however, is a somewhat simpler problem, and may be still useful for synthetic vaccines or as diagnostic tools (Regenmortel and Muller, 1999) . Moreover, the determination of continuous epitope.....
Document: B-cell epitope prediction is a highly challenging field due to the fact that the vast majority of antibodies raised against a specific protein interact with discontinuous fragments (van Regenmortel, 1996) . The prediction of continuous, or linear, epitopes, however, is a somewhat simpler problem, and may be still useful for synthetic vaccines or as diagnostic tools (Regenmortel and Muller, 1999) . Moreover, the determination of continuous epitopes can be integrated into determination of discontinuous epitopes, as these often contain linear stretches (Hopp, 1994) .
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