Author: Kammer, Andreas R.; van der Burg, Sjoerd H.; Grabscheid, Benno; Hunziker, Isabelle P.; Kwappenberg, Kitty M.C.; Reichen, Jürg; Melief, Cornelis J.M.; Cerny, Andreas
Title: Molecular Mimicry of Human Cytochrome P450 by Hepatitis C Virus at the Level of Cytotoxic T Cell Recognition Document date: 1999_7_19
ID: 1vabzhs5_21
Snippet: The HCV core 176 peptide has been described as a target epitope for CTLs that are present in the peripheral blood of patients with chronic HCV infection (10) . This peptide is processed and presented via the endogenous MHC class I pathway (11) . We used PBMCs from healthy, HCV-seronegative individuals as well as from patients with chronic HCV infection to induce primary CTL responses against this epitope and two homologous CYP-derived peptides. C.....
Document: The HCV core 176 peptide has been described as a target epitope for CTLs that are present in the peripheral blood of patients with chronic HCV infection (10) . This peptide is processed and presented via the endogenous MHC class I pathway (11) . We used PBMCs from healthy, HCV-seronegative individuals as well as from patients with chronic HCV infection to induce primary CTL responses against this epitope and two homologous CYP-derived peptides. CTLs induced with the HCV core 178 peptide not only recognized the inducing HCV peptide, but also showed autoreactivity, lysing targets presenting CYP-derived selfpeptides and target cells stably transfected with a plasmid coding for the whole CYP2A6 protein, showing that the CYP epitope is also presented via the endogenous MHC class I pathway. Among the CTLs we could distinguish three different functional types in the same individual: cells recognizing HCV core 178 only, cells with cross-reaction between HCV core 178 and CYP2A7, and cells recognizing HCV core and both CYP epitopes, indicating a polyclonal response against HCV core 178 with a distinct hierarchy.
Search related documents:
Co phrase search for related documents- chronic HCV infection and CYP epitope: 1
- chronic HCV infection and CYP epitope HCV core: 1
- chronic HCV infection and epitope CTL response: 1
- chronic HCV infection and HCV core: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10
- chronic HCV infection and HCV infection: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73, 74
- chronic HCV infection and HCV peptide: 1, 2
- chronic HCV infection and peripheral blood: 1, 2, 3
- chronic HCV infection and primary epitope CTL response: 1
- chronic HCV infection patient and HCV infection: 1
- CTL response and epitope CTL response: 1, 2, 3, 4, 5, 6, 7, 8
- CTL response and HCV core: 1, 2, 3
- CTL response and HCV infection: 1, 2, 3
- CTL response and HCV peptide: 1, 2, 3
- CTL response and MHC class: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12
- CTL response and peripheral blood: 1, 2, 3, 4
- CTL response and primary epitope CTL response: 1
- CTL response and target cell: 1, 2, 3
- CTL response and target epitope: 1
- ctl target epitope and epitope CTL response: 1
Co phrase search for related documents, hyperlinks ordered by date