Nanoparticle Vaccines Adopting Virus-like Features for Enhanced Immune Potentiation

Chattopadhyay, Saborni; Chen, Jui-Yi; Chen, Hui-Wen; Hu, Che-Ming Jack

Later studies using solid nanoparticles on examining the effect of particle size on lymph node delivery echo earlier findings based on liposomes. Using polystyrene beads, Manolova et al. confirmed the size-dependent particle transport in the lymphatic system. Upon subcutaneous delivery, large particles between 500 to 2000 nm were found to be associated with dendritic cells from the site of injection, and small nanoparticles between 20 to 200 nm could drain freely in the lymphatic system, effectively targeting lymph node-resident dendritic cells and macrophages [139] . In a study by Reddy et al. on examining nanocarriers as a vaccine delivery platform, Pluronic-stabilized polypropylene sulfide nanoparticles of well-defined sizes were investigated.