Author: Chattopadhyay, Saborni; Chen, Jui-Yi; Chen, Hui-Wen; Hu, Che-Ming Jack
Title: Nanoparticle Vaccines Adopting Virus-like Features for Enhanced Immune Potentiation Document date: 2017_6_9
ID: 7q2wkwrf_35
Snippet: The size-dependent lymph node targeting was also observed in other solid particle platforms. In a study by Gao et al. that compared 30 nm and 90 nm gold nanoparticles as antigen carriers, 30 nm gold nanoparticles yielded 2.5-fold higher lymph node accumulation in terms of total gold delivery. Upon conversion to particle number and total particle surface area, 30 nm gold nanoparticles had an enhancement of 67-fold and 7.5-fold as compared to 90 nm.....
Document: The size-dependent lymph node targeting was also observed in other solid particle platforms. In a study by Gao et al. that compared 30 nm and 90 nm gold nanoparticles as antigen carriers, 30 nm gold nanoparticles yielded 2.5-fold higher lymph node accumulation in terms of total gold delivery. Upon conversion to particle number and total particle surface area, 30 nm gold nanoparticles had an enhancement of 67-fold and 7.5-fold as compared to 90 nm particles, respectively [154] . In general, nanoparticles between 20 and 200 nm, a length scale that coincides with viral particles, can exploit interstitial flow for lymphatic delivery. Within this length scale, smaller particle size tends to favor lymph node accumulation.
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