Author: Chattopadhyay, Saborni; Chen, Jui-Yi; Chen, Hui-Wen; Hu, Che-Ming Jack
Title: Nanoparticle Vaccines Adopting Virus-like Features for Enhanced Immune Potentiation Document date: 2017_6_9
ID: 7q2wkwrf_55
Snippet: In another work based on PRINT (Particle Replication in Non-wetting Templates) technology, electrostatic interaction was exploited to generate nanoparticle vaccines of cylindrical shape. Cationic particles were prepared by blending positively charged polymers with PLGA prior to the imprint lithography process. Upon mixing with anionic hemagglutinin proteins of influenza viruses, a high level of antigen binding to the particle surface was achieved.....
Document: In another work based on PRINT (Particle Replication in Non-wetting Templates) technology, electrostatic interaction was exploited to generate nanoparticle vaccines of cylindrical shape. Cationic particles were prepared by blending positively charged polymers with PLGA prior to the imprint lithography process. Upon mixing with anionic hemagglutinin proteins of influenza viruses, a high level of antigen binding to the particle surface was achieved [209] . Immunization with the nanoparticle vaccine elicited a more potent anti-influenza antibody response compared to a commercial vaccine based on inactivated subunit influenza viruses. Unlike other spherical nanoparticle vaccines, the platform offers the ability to mimic the filamentous shape that can be found among many virus species.
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