Author: Jartti, Laura; Langen, Henriikka; Söderlund-Venermo, Maria; Vuorinen, Tytti; Ruuskanen, Olli; Jartti, Tuomas
Title: New Respiratory Viruses and the Elderly Document date: 2011_7_6
ID: 7fwzohmu_32
Snippet: The term immunosenescence describes the deleterious age-associated changes in the immune system that render elderly individuals susceptible to infectious disease and increases morbidity and mortality [3, 166] . With age, all components of immunity are affected, but the T cells are the most susceptible [167] . Although the adaptive function of immunity appears to be more seriously affected than the innate immune system, the increased susceptibilit.....
Document: The term immunosenescence describes the deleterious age-associated changes in the immune system that render elderly individuals susceptible to infectious disease and increases morbidity and mortality [3, 166] . With age, all components of immunity are affected, but the T cells are the most susceptible [167] . Although the adaptive function of immunity appears to be more seriously affected than the innate immune system, the increased susceptibility to lower respiratory tract viral infections relates particularly to defective innate immunity [163, 168] . The weakening immune responses could be linked to the over-all long-term poor outcome in the elderly [166] . Immunosenescence is a multifactorial process and is associated with thymic involution, chronic antigenic stimulation (predominantly attributable to persistent infections), signal transduction changes in immune cells, and protein-energy malnutrition [169] . There is a paucity of accurate data on the link between the causes of death of elderly and the age-associated changes in the immune system.
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