Author: Groeneveld, Geert H; van der Reyden, Tanny J; Joosten, Simone A; Bootsma, Hester J; Cobbaert, Christa M; de Vries, Jutte J C; Kuijper, Ed J; van Dissel, Jaap T
Title: Non-lytic antibiotic treatment in community-acquired pneumococcal pneumonia does not attenuate inflammation: the PRISTINE trial Document date: 2019_5_18
ID: 19ueli6e_56
Snippet: Finally, another reason for the absence of detectable LTA in our samples could be the serotypes causing pneumococcal pneumonia. Different pneumococcal isolates have different lytic effects. 33 In an experimental meningitis model in rabbits, serotype 23F caused more LTA release and inflammation than pneumococcal serotype 3. 34 In our study, only one patient had a pneumococcal pneumonia with serotype 23F versus four patients with serotype 3......
Document: Finally, another reason for the absence of detectable LTA in our samples could be the serotypes causing pneumococcal pneumonia. Different pneumococcal isolates have different lytic effects. 33 In an experimental meningitis model in rabbits, serotype 23F caused more LTA release and inflammation than pneumococcal serotype 3. 34 In our study, only one patient had a pneumococcal pneumonia with serotype 23F versus four patients with serotype 3.
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