Author: Joseph, Patrick; Godofsky, Eliot
Title: Outpatient Antibiotic Stewardship: A Growing Frontier—Combining Myxovirus Resistance Protein A With Other Biomarkers to Improve Antibiotic Use Document date: 2018_2_15
ID: 0emio4rl_11
Snippet: Streptococcal carriers are at low risk to spread GABHS to close contacts. They do not require antibiotic treatment and are at minimal risk for development of rheumatic fever [14] . Streptococcal carriage may persist for many months and frequently poses diagnostic challenges when a symptomatic viral URI develops in carriers. The low predictive value of throat swabs relates to the prevalence of carrier rates [15] , and neither the blood agar plate .....
Document: Streptococcal carriers are at low risk to spread GABHS to close contacts. They do not require antibiotic treatment and are at minimal risk for development of rheumatic fever [14] . Streptococcal carriage may persist for many months and frequently poses diagnostic challenges when a symptomatic viral URI develops in carriers. The low predictive value of throat swabs relates to the prevalence of carrier rates [15] , and neither the blood agar plate culture nor the rapid antigen tests can accurately differentiate individuals with true GABHS pharyngitis from GABHS carriers [16] . Studies have shown that only 40%-50% of the children with GABHS isolated from the upper respiratory tract who presented with symptoms of tonsillitis or pharyngitis demonstrated a systemic immune response [16] [17] [18] .
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