Author: Joseph, Patrick; Godofsky, Eliot
Title: Outpatient Antibiotic Stewardship: A Growing Frontier—Combining Myxovirus Resistance Protein A With Other Biomarkers to Improve Antibiotic Use Document date: 2018_2_15
ID: 0emio4rl_23
Snippet: PCT is the peptide precursor of calcitonin, a hormone that is synthesized by the parafollicular C cells of the thyroid and regulates calcium homeostasis. Standard reference values of PCT in adults and children older than 72 hours are usually 0.15 ng/mL or less [39] . In response to inflammation associated with bacterial endotoxin or inflammatory cytokines, PCT elevates within 2-6 hours, peaks at 12-24 hours, and has a half-life of 25-40 hours [37.....
Document: PCT is the peptide precursor of calcitonin, a hormone that is synthesized by the parafollicular C cells of the thyroid and regulates calcium homeostasis. Standard reference values of PCT in adults and children older than 72 hours are usually 0.15 ng/mL or less [39] . In response to inflammation associated with bacterial endotoxin or inflammatory cytokines, PCT elevates within 2-6 hours, peaks at 12-24 hours, and has a half-life of 25-40 hours [37, 40] . Higher procalcitonin levels in patients with bacterial sepsis are associated with a greater likelihood of severe sepsis, septic shock, and decreased survival [40] . Colonization or carrier states without a systemic host response do not significantly raise procalcitonin levels [41] . Procalcitonin levels fall with successful treatment of either severe bacterial infection or noninfectious inflammatory stimuli [40] .
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