Author: Li, Xinyu; Huang, Lei; Gao, Weijie
Title: Overexpression of Tripartite Motif Conaining 55 (TRIM55) Inhibits Migration and Invasion of Hepatocellular Carcinoma (HCC) Cells via Epithelial-Mesenchymal Transition and Matrix Metalloproteinase-2 (MMP2) Document date: 2019_1_27
ID: 037d5r9i_25
Snippet: Because expression of TRIM55 was associated with vessel invasion in HCC patients, we hypothesized that TRIM55 plays vital role in cell migration and invasion. The results of Transwell assay showed that the cell migration and invasion ability of HCC cell lines were significantly decreased after overexpression of TRIM55 ( Figure 3A, 3B) . Because the EMT process and matrix metalloproteinase family proteins were found to be 776 important for cell mi.....
Document: Because expression of TRIM55 was associated with vessel invasion in HCC patients, we hypothesized that TRIM55 plays vital role in cell migration and invasion. The results of Transwell assay showed that the cell migration and invasion ability of HCC cell lines were significantly decreased after overexpression of TRIM55 ( Figure 3A, 3B) . Because the EMT process and matrix metalloproteinase family proteins were found to be 776 important for cell migration and invasion, we assessed the expression of related proteins by IF and Western blot, and the results showed that expression of E-cadherin was increased while expressions of Vimentin and MMP2 were decreased under the condition of TRIM55 overexpression ( Figure 4A, 4B ).
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