Author: Rao, Xiaoquan; Zhao, Shi; Braunstein, Zachary; Mao, Hong; Razavi, Michael; Duan, Lihua; Wei, Yingying; Toomey, Amelia C.; Rajagopalan, Sanjay; Zhong, Jixin
Title: Oxidized LDL upregulates macrophage DPP4 expression via TLR4/TRIF/CD36 pathways Document date: 2019_2_7
ID: 1n7xjjd5_37
Snippet: Our prior study has shown that DPP4 expression is markedly increased on the surface of antigen presenting cells (APCs) such as macrophages and dendritic cells in the visceral adipose of obese humans, with the levels of DPP4 expression on APC's positively correlating with the degree of insulin resistance [8] . In line with these findings, Sell et al. also confirmed the up-regulation of adipose tissue DPP4 in obese insulin resistant subjects and ad.....
Document: Our prior study has shown that DPP4 expression is markedly increased on the surface of antigen presenting cells (APCs) such as macrophages and dendritic cells in the visceral adipose of obese humans, with the levels of DPP4 expression on APC's positively correlating with the degree of insulin resistance [8] . In line with these findings, Sell et al. also confirmed the up-regulation of adipose tissue DPP4 in obese insulin resistant subjects and adipose tissue DPP4 was correlated with measures of insulin resistance and inflammation [9] . These findings clearly implicate DPP4 as a marker/mediator of inflammation in adipose tissue.
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