Author: Fausther-Bovendo, Hugues; Kobinger, Gary P
Title: Pre-existing immunity against Ad vectors: Humoral, cellular, and innate response, what's important? Document date: 2014_11_1
ID: 3894l9qi_6_1
Snippet: zation is due to high sequence heterogeneity of targeted epitopes such as hexon HVR or fiber knob. 19, 21, 23, 24 However, non-neutralizing but cross-reactive Ab are also generated, especially after repeated Ad injections. 25 These non-neutralizing Abs can also reduce transgene expression, presumably using various Fc receptor dependent (such as antibody dependent cellular cytotoxicity, complement mediated lysis or opsonisation) and independent me.....
Document: zation is due to high sequence heterogeneity of targeted epitopes such as hexon HVR or fiber knob. 19, 21, 23, 24 However, non-neutralizing but cross-reactive Ab are also generated, especially after repeated Ad injections. 25 These non-neutralizing Abs can also reduce transgene expression, presumably using various Fc receptor dependent (such as antibody dependent cellular cytotoxicity, complement mediated lysis or opsonisation) and independent mechanisms. The impact of non-neutralizing Abs was elegantly illustrated by Pichla-Gollon and colleagues who demonstrated that passive transfer of an Ab able to bind, but not neutralize, could reduce transgene expression as well as immunogenicity of a modified Chad68 vector. 26 The inhibitory effect of cross-reactive but non neutralizing Ab is of particular concern, as these Abs seem to be readily inducible. 25
Search related documents:
Co phrase search for related documents- dependent cellular cytotoxicity and non neutralize: 1
- dependent cellular cytotoxicity and passive transfer: 1
- dependent cellular cytotoxicity and targeted epitope: 1
- Fc receptor and passive transfer: 1, 2
- independent mechanism and inhibitory effect: 1, 2, 3
- inhibitory effect and particular concern: 1, 2, 3
- inhibitory effect and passive transfer: 1
- inhibitory effect and transgene expression: 1, 2
- inhibitory effect and transgene expression reduce: 1
- non neutralize and targeted epitope: 1
- passive transfer and transgene expression: 1, 2
- passive transfer and transgene expression reduce: 1
Co phrase search for related documents, hyperlinks ordered by date