Selected article for: "distribution pattern and vector dna amount"
Author: Riede, O; Seifert, K; Oswald, D; Endmann, A; Hock, C; Winkler, A; Salguero, F J; Schroff, M; Croft, S L; Juhls, C
Title: Preclinical safety and tolerability of a repeatedly administered human leishmaniasis DNA vaccine
  • Document date: 2015_4_30
    • ID: 4eyn7pjq_17
    Snippet: At day 14 after the fourth injection, vectors were cleared from nearly all organs except from skin and inguinal lymph nodes. Whereas the amount of vector DNA in skin samples was~10-fold lower compared with 24 h after the last injection, vector copy numbers in inguinal lymph node samples were reduced 100-fold. This finding is in line with reports on i.d.-administered plasmid DNA vaccines, [27] [28] [29] suggesting that plasmids and MIDGE-Th1 vecto.....
    Document: At day 14 after the fourth injection, vectors were cleared from nearly all organs except from skin and inguinal lymph nodes. Whereas the amount of vector DNA in skin samples was~10-fold lower compared with 24 h after the last injection, vector copy numbers in inguinal lymph node samples were reduced 100-fold. This finding is in line with reports on i.d.-administered plasmid DNA vaccines, [27] [28] [29] suggesting that plasmids and MIDGE-Th1 vectors ( 21 and this report) follow a similar pattern of distribution and persistence.

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