Proceedings of the Food and Drug Administration public workshop on pathogen reduction technologies for blood safety 2018 (Commentary, p. 3026)

Atreya, Chintamani; Glynn, Simone; Busch, Michael; Kleinman, Steve; Snyder, Edward; Rutter, Sara; AuBuchon, James; Flegel, Willy; Reeve, David; Devine, Dana; Cohn, Claudia; Custer, Brian; Goodrich, Raymond; Benjamin, Richard J.; Razatos, Anna; Cancelas, Jose; Wagner, Stephen; Maclean, Michelle; Gelderman, Monique; Cap, Andrew; Ness, Paul

Speaker's summary: The Mirasol PRT system is CE marked for the treatment of PLTs, plasma, and WB for transfusion and is in routine use in many countries outside of the United States. The Mirasol PRT system uses one device to treat all blood products. Mirasol consists of the photosensitizer riboflavin (vitamin B2) in combination with UV light to irreversibly damage DNA and RNA resulting in inactivation of viruses, bacteria, parasites, and WBCs. Because riboflavin and its photoproducts are nontoxic and naturally occurring, they do not require removal from the blood product after treatment.