Retrospective Multicenter Study of Respiratory Syncytial Virus Prophylaxis in Korean Children with Congenital Heart Diseases

Kim, Ah Young; Jung, Se Yong; Choi, Jae Young; Kim, Gi Beom; Kim, Young-Hwue; Shim, Woo Sup; Kang, I-Seok; Jung, Jo Won

Cardiomyopathies as well as other structural heart diseases are major risk factors for RSV hospitalization in infants with CHD. 20)29)30) Furthermore, in our study, HCM patients were placed into the high risk group with respect to RSV infection because 66.6% (n=2) had contracted RSV infection and 20% (n=1) of all RSVrelated mortality occurred in the HCM group. Stagnant pulmonary flow due to cardiomyopathy results in significantly abnormal hemodynamics with perivascular infiltrates, leading to altered vascular tone and permeability changes in the alveolar-capillary interface, which is further exaggerated by the inflammation caused by RSV. 29) Therefore, the USA, UK, Japan, France, and Austria have adopted the recommendations for infants with cardiomyopathy as co-morbidity. 8) These findings should be taken into consideration when deciding which children should receive prophylaxis.