Author: Poltronieri, Palmiro; Sun, Binlian; Mallardo, Massimo
Title: RNA Viruses: RNA Roles in Pathogenesis, Coreplication and Viral Load Document date: 2015_10_23
ID: 259cspey_32
Snippet: Four vsRNAs were detected in enterovirus 71-infected cells using next-generation sequencing and northern blots. Viral infection produced substantial levels (>10 5 copy numbers per cell) of vsRNA1, one of the four vsRNAs. Dicer was shown to be involved in vsRNA1 generation in infected cells. vsRNA1 overexpression inhibited viral translation and IRES activity in infected cells. Conversely, blocking vsRNA1 enhanced viral yield and viral protein synt.....
Document: Four vsRNAs were detected in enterovirus 71-infected cells using next-generation sequencing and northern blots. Viral infection produced substantial levels (>10 5 copy numbers per cell) of vsRNA1, one of the four vsRNAs. Dicer was shown to be involved in vsRNA1 generation in infected cells. vsRNA1 overexpression inhibited viral translation and IRES activity in infected cells. Conversely, blocking vsRNA1 enhanced viral yield and viral protein synthesis. vsRNA1 targets stem-loop II of the viral 5' untranslated region and inhibits the activity of the IRES through this sequence-specific targeting [37] .
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