Selected article for: "IFN protein and mRNA level"
Author: Poltronieri, Palmiro; Sun, Binlian; Mallardo, Massimo
Title: RNA Viruses: RNA Roles in Pathogenesis, Coreplication and Viral Load
  • Document date: 2015_10_23
    • ID: 259cspey_55
    Snippet: Zahoor et al. using microarray system found that Vpr protein enhanced the mRNA level of interferon (IFN)stimulated genes (ISGs), and causes phosphorylation of STAT1 at tyrosine 701 in human monocyte-derived macrophages (MDMs) infected with a recombinant adenovirus expressing Vpr [80] . These findings enhance the current understanding of HIV-1 replication and pathogenesis in human macrophages. Vpr, together with other HIV factors, recruits cellula.....
    Document: Zahoor et al. using microarray system found that Vpr protein enhanced the mRNA level of interferon (IFN)stimulated genes (ISGs), and causes phosphorylation of STAT1 at tyrosine 701 in human monocyte-derived macrophages (MDMs) infected with a recombinant adenovirus expressing Vpr [80] . These findings enhance the current understanding of HIV-1 replication and pathogenesis in human macrophages. Vpr, together with other HIV factors, recruits cellular adaptors to facilitate immune evasion [81] . HIV-1 Vpr differentially regulates the expression levels of chemotactic cytokines such as CXCL1, CXCL5, CXCL7, CXCL9, CXCL10, and CXCL11. A report showed that CXCL10 and CXCL11 are up-regulated in HIV-1-infected macrophages and play a key role in the recruitment and spread of HIV-1 to susceptible CD4+ T-cells [82] .

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