Author: Vergara-Alert, Júlia; Vidal, Enric; Bensaid, Albert; Segalés, Joaquim
Title: Searching for animal models and potential target species for emerging pathogens: Experience gained from Middle East respiratory syndrome (MERS) coronavirus Document date: 2017_3_3
ID: 28vx9w58_13
Snippet: Dromedary camels are the main source of MERS-CoV zoonotic transmission (reviewed in [52] ). In experimental intranasal inoculations with MERS-CoV, only mild clinical signs (i.e. nasal discharge) with URT infection were observed. Viral RNA was detected in nasal swabs, in upper and lower respiratory tracts, and also in extra-pulmonary tissues (i.e. lymph nodes, tonsil, intestine, liver, adrenal gland, etc.). In contrast, infectious virus was only d.....
Document: Dromedary camels are the main source of MERS-CoV zoonotic transmission (reviewed in [52] ). In experimental intranasal inoculations with MERS-CoV, only mild clinical signs (i.e. nasal discharge) with URT infection were observed. Viral RNA was detected in nasal swabs, in upper and lower respiratory tracts, and also in extra-pulmonary tissues (i.e. lymph nodes, tonsil, intestine, liver, adrenal gland, etc.). In contrast, infectious virus was only detected in the URT, trachea, large bronchus and tracheobronchial lymph node. Gross lesions were not observed in dromedary camels, but inflammation in the nasal cavity, trachea and bronchus was present. The virus replication in dromedaries was only detected in epithelial cells in the URT [47, 53] .
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