Author: Fu, Yu; Lee, Inhan; Lee, Yong Sun; Bao, Xiaoyong
Title: Small Non-coding Transfer RNA-Derived RNA Fragments (tRFs): Their Biogenesis, Function and Implication in Human Diseases Document date: 2015_12_31
ID: 0b08jyjs_6
Snippet: The tRF-5 series were the first identified class of tRFs and were usually formed by a cleavage in the D or anticodon loop of a mature tRNA. They have been reported in mammalian cells, plants, and fission yeast [3, [33] [34] [35] [36] . As aforementioned, the tRF-3 series are those derived from the 3ËŠ-end of a mature tRNA, usually by cleavage in the T loop [3, 32, [37] [38] [39] . As the 3ËŠ-end of mature tRNAs is the acceptor trinucleotide CCA, .....
Document: The tRF-5 series were the first identified class of tRFs and were usually formed by a cleavage in the D or anticodon loop of a mature tRNA. They have been reported in mammalian cells, plants, and fission yeast [3, [33] [34] [35] [36] . As aforementioned, the tRF-3 series are those derived from the 3ËŠ-end of a mature tRNA, usually by cleavage in the T loop [3, 32, [37] [38] [39] . As the 3ËŠ-end of mature tRNAs is the acceptor trinucleotide CCA, the tRF-3 series also characteristically has an end CCA. The tRF-1 series are undoubtedly the RNase Z cleavage product of a pre-tRNA, because their 5ËŠends begin immediately after the 3ËŠ-terminus of the mature tRNA and their 3ËŠ-ends are a series of U residues that are residual from RNA polymerase III transcription run-off [3, 32, 40, 41] . Overall, the cleavage of tRFs is very much structure-dependent, suggesting they are not randomly degraded products.
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