Author: Mateo, Roberto; Nagamine, Claude M.; Kirkegaard, Karla
Title: Suppression of Drug Resistance in Dengue Virus Document date: 2015_12_15
ID: 6bx2nrui_21
Snippet: For ST-148, drug-susceptible viruses were found to be dominant inhibitors of drug-resistant viruses in deliberate coinfections performed for single infectious cycles in cultured cells (Fig. 1D) . Even at ratios of 1:1, significant inhibition of drug-resistant viral growth by coinfection with drug-susceptible virus was observed. Assuming random assembly, this argues that as much as 50% of an oligomeric assemblage of core protein can be composed of.....
Document: For ST-148, drug-susceptible viruses were found to be dominant inhibitors of drug-resistant viruses in deliberate coinfections performed for single infectious cycles in cultured cells (Fig. 1D) . Even at ratios of 1:1, significant inhibition of drug-resistant viral growth by coinfection with drug-susceptible virus was observed. Assuming random assembly, this argues that as much as 50% of an oligomeric assemblage of core protein can be composed of drugresistant subunits and remain phenotypically drug susceptible. Such a ratio certainly underestimates the effect that would be seen during an actual infection, during which it would be much more likely for a drug-resistant variant to be created in a cell that already contained dozens, or hundreds, of drug-susceptible genomes.
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