Selected article for: "early innate and immune response"
Author: Rechtien, Anne; Richert, Laura; Lorenzo, Hadrien; Martrus, Gloria; Hejblum, Boris; Dahlke, Christine; Kasonta, Rahel; Zinser, Madeleine; Stubbe, Hans; Matschl, Urte; Lohse, Ansgar; Krähling, Verena; Eickmann, Markus; Becker, Stephan; Thiébaut, Rodolphe; Altfeld, Marcus; Addo, Marylyn
Title: Systems Vaccinology Identifies an Early Innate Immune Signature as a Correlate of Antibody Responses to the Ebola Vaccine rVSV-ZEBOV
  • Document date: 2017_8_29
    • ID: 7tscp04v_2
    Snippet: The systems vaccinology approach presented here comprehensively dissects innate immunity profiles to rVSV-ZEBOV and reveals strong and early innate immune activation following vaccination. A subset of early innate markers, encompassing interferon-g-inducible protein 10 (IP-10) and subsets of monocytes, dendritic cells, and natural killer (NK) cells as well as an early gene signature linked to the IP-10 pathway, were identified as innate immune si.....
    Document: The systems vaccinology approach presented here comprehensively dissects innate immunity profiles to rVSV-ZEBOV and reveals strong and early innate immune activation following vaccination. A subset of early innate markers, encompassing interferon-g-inducible protein 10 (IP-10) and subsets of monocytes, dendritic cells, and natural killer (NK) cells as well as an early gene signature linked to the IP-10 pathway, were identified as innate immune signatures that correlate with the GP-specific antibody response on day 28 and beyond. Because human data on the recombinant VSV vaccine platform are scarce, our study makes important contributions to the understanding of the immunological properties of this vaccine in humans and may provide unique insights for future use of this vector technology in emergency vaccines, including candidate vaccines currently in development against Zika virus (Betancourt et al., 2017) .

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